Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | KIT | P10721 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406155 | 0.86 | MAPK14 (0.63) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL398273 | 0.86 | MAPK14 (0.63) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL397516 | 0.86 | MAPK14 (0.63) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL396047 | 0.84 | MAPK14 (0.48) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL398290 | 0.84 | MAPK14 (0.48) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL602310 | 0.78 | MAPK14 (0.46) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL10203408 | 0.75 | MAPK14 (0.41) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL3955501 | 0.75 | MAPK14 (0.54) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL4576512 | 0.74 | MAPK14 (0.56) | MAPK14KITKDRMAPK9LCK | |
| SCHEMBL4576490 | 0.74 | MAPK14 (0.56) | MAPK14KITKDRMAPK9LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042649-A2 | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2010-04-15 | — | — | WO | disclosed |