Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.54 |
| ▸ | KIT | P10721 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL393973 | 0.85 | MAPK14 (0.73) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL396376 | 0.85 | MAPK14 (0.73) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL4576512 | 0.83 | MAPK14 (0.56) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL4576490 | 0.83 | MAPK14 (0.56) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL393447 | 0.83 | MAPK14 (0.56) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL435291 | 0.82 | CDK2 (0.43) | MAPK14KDRMAPK9LCKLYN | |
| SCHEMBL437501 | 0.82 | CDK2 (0.43) | MAPK14KDRMAPK9LCKLYN | |
| SCHEMBL1406123 | 0.76 | MAPK14 (0.77) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL1406009 | 0.76 | MAPK14 (0.77) | MAPK14KDRKITMAPK9LCK | |
| SCHEMBL439662 | 0.76 | CDK2 (0.45) | MAPK14KDRMAPK9LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2077998-A1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008030466-A1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2008-03-13 | — | — | WO | disclosed |