Toluene

Toluene

SCHEMBL27870779

Cc1ccccc1.O=C(O)C1CNCC(O)C1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
REN P00797 2/20 0.39
SLC6A11 P48066 1/20 0.39
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
MC4R P32245 1/20 0.37
AKR1C3 P42330 1/20 0.37
AKR1C1 Q04828 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA7 P36544 1/20 0.36
CHRNA4 P43681 1/20 0.36
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
ALOX12 P18054 1/20 0.35
ACHE P22303 1/20 0.35
NOTUM Q6P988 1/20 0.35
HTR2C P28335 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL27887158 0.82 LMNA (0.52) CES2CES1MC4RSMN1; SMN2CHRNB2
SCHEMBL1248551 0.82 CYP2D6 (0.46) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL1248549 0.82 CYP2D6 (0.46) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL1227337 0.82 CYP2D6 (0.46) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL404587 0.82 CYP2D6 (0.46) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL28087162 0.80 CYP2D6 (0.45) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL4303701 0.80 CYP2D6 (0.45) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
SCHEMBL4303695 0.80 CYP2D6 (0.45) SLC6A11SMN1; SMN2CHRNB2CHRNB4CHRNA3
Toluene SCHEMBL27870793 0.77 SLC6A2 (0.40) RENSLC6A11MC4RSMN1; SMN2HTR2C
SCHEMBL27297309 0.73 HTR2C (0.49) AKR1C3AKR1C1SMN1; SMN2CHRNB2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102498107-A Heteroaryl compounds as kinase inhibitors NOVARTIS AG 2012-06-13 CN disclosed
CN-102482265-A Pyrazinylpyridines useful for the treatment of proliferative diseases NOVARTIS AG 2012-05-30 CN disclosed
CN-102471310-A Bipyridines useful for the treatment of proliferative diseases NOVARTIS AG 2012-05-23 CN disclosed