Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | SDHB | P21912 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352449 | 0.84 | ALDH1A1 (0.49) | MAPTALDH1A1TSHRMAPK14TP53 | |
| SCHEMBL10146309 | 0.79 | MAPK14 (0.43) | MAPTALDH1A1HPGDTSHRMAPK14 | |
| SCHEMBL2565757 | 0.78 | HCAR2 (0.52) | EPHX2HDAC4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL444734 | 0.78 | MAPT (0.42) | NOTUMMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL27859721 | 0.78 | EPHX2 (0.38) | EPHX2HDAC4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL12076049 | 0.77 | SCD (0.39) | EPHX2MAPTHDAC4KDM4EALDH1A1 | |
| SCHEMBL27876364 | 0.77 | HCAR2 (0.50) | EPHX2HDAC4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL7055336 | 0.76 | MAPT (0.43) | NOTUMMAPTKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5752843 | 0.74 | NR1H2 (0.39) | NOTUMMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL4034128 | 0.74 | HCAR2 (0.62) | MAPTALDH1A1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102686571-B | tricyclic heterocyclic compounds | BRISTOL-MYERS SQUIBB CO. (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-102686571-A | Tricyclic heterocyclic compounds | BRISTOL MYERS SQUIBB CO | 2012-09-19 | — | — | CN | disclosed |