Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.49 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | AGER | Q15109 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28943518 | 0.98 | PTGS2 (0.48) | PTGS2MKNK1MKNK2KMOCYP2A6 | |
| SCHEMBL28274745 | 0.89 | PTGS2 (0.51) | PTGS2MKNK1MKNK2KMOCYP2A6 | |
| SCHEMBL25779250 | 0.82 | MKNK1 (0.53) | PTGS2MKNK1MKNK2KMOCYP2A6 | |
| Benzene SCHEMBL15456827 | 0.81 | PTGS2 (0.62) | PTGS2MKNK1MKNK2CYP2A6KDM4E | |
| Benzene SCHEMBL28446151 | 0.81 | PTGS2 (0.62) | PTGS2MKNK1MKNK2CYP2A6KDM4E | |
| Benzene SCHEMBL9109284 | 0.81 | PTGS2 (0.62) | PTGS2MKNK1MKNK2CYP2A6KDM4E | |
| Acetic Acid SCHEMBL28287133 | 0.81 | PTGS2 (0.62) | PTGS2MKNK1MKNK2KMOCYP2A6 | |
| Acetic Acid SCHEMBL28287192 | 0.81 | PTGS2 (0.62) | PTGS2MKNK1MKNK2KMOCYP2A6 | |
| SCHEMBL28182272 | 0.80 | PTGS2 (0.54) | PTGS2CYP2A6KDM4EALDH1A1CYP3A4 | |
| SCHEMBL11067761 | 0.80 | PTGS2 (0.60) | PTGS2CYP2A6KDM4EALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482257-A | Apoptosis signal-modulating kinase inhibitors | GILEAD SCIENCES INC | 2012-05-30 | — | — | CN | claimed |
| CN-102482257-B | Apoptosis signal-modulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| CN-102482257-A | Apoptosis signal-modulating kinase inhibitors | GILEAD SCIENCES INC | 2012-05-30 | — | — | CN | disclosed |