Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.57 |
| ▸ | JAK2 | O60674 | 4/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.57 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | FLT1 | P17948 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 3/20 | 0.57 |
| ▸ | CLK2 | P49760 | 3/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.57 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.57 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL68662 | 0.98 | DYRK1A (0.58) | DYRK1AJAK2CDK5AURKAMAP4K4 | |
| SCHEMBL15241762 | 0.79 | BRD4 (0.49) | DYRK1AJAK2CDK5AURKAMAP4K4 | |
| Valine SCHEMBL18860660 | 0.78 | DYRK1A (0.44) | DYRK1AJAK2CDK5AURKAMAP4K4 | |
| Ammonia Solution, Strong SCHEMBL27890807 | 0.78 | JAK2 (0.57) | JAK2FLT1KDRAURKBFLT3 | |
| SCHEMBL1880862 | 0.76 | BRD4 (0.47) | DYRK1AMAP4K4CLK2CLK4ROCK2 | |
| SCHEMBL1564760 | 0.76 | ITK (0.54) | DYRK1AJAK2CDK5AURKAMAP4K4 | |
| SCHEMBL1053943 | 0.76 | JAK2 (0.58) | JAK2FLT1KDRAURKBFLT3 | |
| SCHEMBL11968454 | 0.76 | BRD4 (0.47) | DYRK1AJAK2CDK5AURKAMAP4K4 | |
| SCHEMBL11968456 | 0.76 | DYRK1A (0.54) | DYRK1AJAK2CDK5AURKAMAP4K4 | |
| SCHEMBL1045946 | 0.76 | BRD4 (0.54) | DYRK1AJAK2CDK5AURKAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102695417-A | Compounds and methods for kinase modulation and indications therefor | PLEXXIKON INC | 2012-09-26 | — | — | CN | disclosed |