Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1045946 | 0.80 | BRD4 (0.54) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL7912970 | 0.80 | BRD4 (0.47) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL68662 | 0.80 | DYRK1A (0.58) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL1880862 | 0.80 | BRD4 (0.47) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL11968454 | 0.80 | BRD4 (0.47) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL28408295 | 0.80 | DYRK1A (0.44) | AXLCDK8TNIKDYRK1AJAK2 | |
| SCHEMBL1053943 | 0.80 | JAK2 (0.58) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL31228005 | 0.80 | BRD4 (0.54) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL20292802 | 0.76 | AXL (0.45) | BRD4MAPK1AXLCDK8TNIK | |
| SCHEMBL19787915 | 0.76 | BRD4 (0.47) | BRD4MAPK1AXLCDK8TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2038272-B1 | PYRIDINONYL PDK1 INHIBITORS | SUNESIS PHARMACEUTICALS INC (US) | 2013-09-04 | — | — | EP | disclosed |