Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.90 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.35 |
| ▸ | DPYD | Q12882 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL5089507 | 0.95 | — | — | |
| Uracil SCHEMBL3798527 | 0.95 | CRBN (1.00) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL11607890 | 0.95 | — | — | |
| Uracil SCHEMBL8235 | 0.95 | — | — | |
| Uracil SCHEMBL11130705 | 0.92 | — | — | |
| Uracil SCHEMBL16116311 | 0.92 | — | — | |
| Uracil SCHEMBL710130 | 0.92 | — | — | |
| Uracil SCHEMBL4664232 | 0.92 | CRBN (0.94) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL21385227 | 0.92 | — | — | |
| Uracil SCHEMBL2161716 | 0.92 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117396231-A | Combination therapy using a combination of an anti-BCMA Antibody Drug Conjugate (ADC) and a Gamma Secretase Inhibitor (GSI) | 新基公司 | 2024-01-12 | — | — | CN | disclosed |
| CN-117337174-A | Transdermal pharmaceutical formulation comprising CBD or THC for the treatment of cancer | 长矛治疗股份有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-111329989-A | TEC family kinase inhibitor adjuvant therapy | 药品循环有限责任公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-108175749-A | The solid dispersions of melt extrusion containing cell death inducer | 艾伯维爱尔兰无限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-103167867-B | Solid dispersion containing apoptosis-inducing medicament | ABBVIE 公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-105820138-A | ABT-263 crystalline forms and solvates for use in treating BCL-2 protein related diseases | ABBVIE 公司 | 2016-08-03 | — | — | CN | disclosed |
| CN-105274170-A | METHODS AND COMPOSITION FOR SECRETION OF HETEROLOGOUS POLYPEPTIDES | GENENTECH INC | 2016-01-27 | — | — | CN | disclosed |
| CN-102933600-B | Methods and compositions for secretion of heterologous polypeptides | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-25 | — | — | CN | disclosed |
| CN-104994858-A | TEC family kinase inhibitor adjuvant therapy | PHARMACYCLICS INC | 2015-10-21 | — | — | CN | disclosed |
| CN-103002880-B | Solid dispersions containing kinase inhibitors | ABBVIE INC | 2015-01-28 | — | — | CN | disclosed |
| CN-104168915-A | Methods of treating cancer | FIVE PRIME THERAPEUTICS INC | 2014-11-26 | — | — | CN | disclosed |
| CN-103987406-A | Compositions containing kinase inhibitors | ABBVIE INC | 2014-08-13 | — | — | CN | disclosed |
| CN-103282025-A | Melt-extruded solid dispersions containing apoptosis-inducing agents | ABBVIE INC | 2013-09-04 | — | — | CN | disclosed |
| CN-103167867-A | Solid dispersions containing an apoptosis-inducing agent | ABBOTT LAB | 2013-06-19 | — | — | CN | disclosed |
| CN-103002880-A | Solid dispersions containing kinase inhibitors | ABBOTT LAB | 2013-03-27 | — | — | CN | disclosed |
| CN-102695507-A | Combination therapy for treating cancer and diagnostic assays for use therein | ABBOTT LAB | 2012-09-26 | — | — | CN | disclosed |