SCHEMBL278746

SCHEMBL278746

Cc1cn([C@H]2C[C@@H](OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(=O)[nH]c(N)nc54)C[C@H]3OP(=O)(O)OC[C@H]3O[C@@H](n4ccc(N)nc4=O)C[C@H]3OP(=O)(O)C(C)C)[C@@H](CC(C)C)O2)c(=O)[nH]c1=O

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TERT O14746 2/20 0.56
DTYMK P23919 4/20 0.51
F2 P00734 3/20 0.50
P2RY2 P41231 1/20 0.45
P2RY4 P51582 1/20 0.45
P2RY6 Q15077 1/20 0.45
RNASEL Q05823 5/20 0.43
FUT5 Q11128 1/20 0.42
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20827711 0.95 TERT (0.53) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29359812 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29429631 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29360218 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29774178 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29923029 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL15127423 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29503590 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL30508522 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4
SCHEMBL29492472 0.90 TERT (0.62) TERTDTYMKF2P2RY2P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8133984-B2 Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids PENTABASE APS (DK) 2012-03-13 US disclosed
US-20100068704-A1 OLIGONUCLEOTIDES COMPRISING SIGNALLING PAIRS AND HYDROPHOBIC NUCLEOTIDES, STEMLESS BEACONS, FOR DETECTION OF NUCLEIC ACIDS, METHYLATION STATUS AND MUTANTS OF NUCLEIC ACIDS PENTABASE APS (DK) 2010-03-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100068704-A1 OLIGONUCLEOTIDES COMPRISING SIGNALLING PAIRS AND HYDROPHOBIC NUCLEOTIDES, STEMLESS BEACONS, FOR DETECTION OF NUCLEIC ACIDS, METHYLATION STATUS AND MUTANTS OF NUCLEIC ACIDS DNMT1, DNMT3A, DNMT3L TERT 347/4885DTYMK 77/4885F2 4842/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.