Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 19/20 | 0.48 |
| ▸ | TPH2 | Q8IWU9 | 10/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870506 | 1.00 | TPH1 (0.48) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL869801 | 0.99 | TPH1 (0.48) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL27747384 | 0.99 | TPH1 (0.48) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL27892947 | 0.92 | TPH1 (0.45) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL869680 | 0.92 | TPH1 (0.50) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL27726676 | 0.92 | TPH1 (0.46) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL870039 | 0.91 | TPH1 (0.51) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL869064 | 0.89 | TPH1 (0.51) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL27726672 | 0.89 | TPH1 (0.51) | TPH1TPH2F2ESR1ADORA3 | |
| SCHEMBL27892907 | 0.89 | TPH1 (0.62) | TPH1TPH2F2ESR1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102711757-A | Methods and assays for treating irritable bowel syndrome | LEXICON PHARMACEUTICALS INC | 2012-10-03 | — | — | CN | disclosed |