Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | ACLY | P53396 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | FABP1 | P07148 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.50 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27879326 | 0.82 | KMT2A (0.58) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL29261775 | 0.82 | MEN1 (0.58) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL29261788 | 0.82 | MEN1 (0.57) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL29261781 | 0.82 | MEN1 (0.54) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL27863059 | 0.81 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2275453 | 0.80 | ACLY (0.76) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL27848619 | 0.80 | NPC1 (0.48) | NPC1RAB9ADHODHHDAC2HDAC1 | |
| SCHEMBL27786187 | 0.79 | PTPN1 (0.58) | DHODH | |
| SCHEMBL28796381 | 0.79 | AVPR2 (0.56) | NPC1RAB9AKMT2AMAPTACLY | |
| SCHEMBL27863054 | 0.78 | ACLY (0.55) | NPC1RAB9AMAPTACLYPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574778-A | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2012-07-11 | — | — | CN | claimed |
| CN-102574778-A | Novel biphenyl and phenyl-pyridine amides | HOFFMANN LA ROCHE | 2012-07-11 | — | — | CN | disclosed |