Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17941675 | 0.84 | TLR8 (0.39) | TRPV1TLR8NPC1JAK2RAB9A | |
| SCHEMBL11769407 | 0.80 | TLR8 (0.46) | TRPV1TLR8ELANE | |
| SCHEMBL4763663 | 0.79 | NPC1 (0.42) | NPC1JAK2RAB9APAX8ALDH1A1 | |
| SCHEMBL3055011 | 0.73 | NPC1 (0.65) | NPC1JAK2RAB9APAX8ALDH1A1 | |
| SCHEMBL11635003 | 0.73 | SPHK2 (0.50) | NPC1RAB9AALDH1A1 | |
| SCHEMBL28221454 | 0.73 | TRPV1 (0.35) | TRPV1RAB9APTPN11 | |
| SCHEMBL6424475 | 0.72 | NPC1 (0.68) | NPC1JAK2RAB9APAX8ALDH1A1 | |
| SCHEMBL1082836 | 0.72 | NPC1 (0.68) | NPC1JAK2RAB9APAX8ALDH1A1 | |
| SCHEMBL11344801 | 0.72 | NPC1 (0.68) | NPC1JAK2RAB9APAX8ALDH1A1 | |
| SCHEMBL7096422 | 0.72 | NPC1 (0.68) | NPC1JAK2RAB9APAX8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104292170-A | Quinazolinyl-aryl urea derivatives with antitumor function and application thereof | UNIV GUANGXI NORMAL | 2015-01-21 | — | — | CN | disclosed |
| CN-104292170-A | Quinazolinyl-aryl urea derivatives with antitumor function and application thereof | UNIV GUANGXI NORMAL | 2015-01-21 | — | — | CN | disclosed |
| CN-102532103-B | Quinazolinyl aryl urea derivatives and preparation method and application thereof | TIANJIN INST PHARM RESEARCH | 2014-07-09 | — | — | CN | disclosed |
| CN-102532103-B | Quinazolinyl aryl urea derivatives and preparation method and application thereof | TIANJIN INST PHARM RESEARCH | 2014-07-09 | — | — | CN | disclosed |
| CN-102532103-A | Quinazolinyl aryl urea derivatives and preparation method and application thereof | TIANJIN INST PHARM RESEARCH | 2012-07-04 | — | — | CN | disclosed |
| CN-102532103-A | Quinazolinyl aryl urea derivatives and preparation method and application thereof | TIANJIN INST PHARM RESEARCH | 2012-07-04 | — | — | CN | disclosed |