Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL232458 | 0.90 | PDGFRB (0.65) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| Bromide SCHEMBL8728376 | 0.88 | PDGFRB (0.62) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL27600512 | 0.88 | PDGFRB (0.62) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL28205439 | 0.88 | PDGFRB (0.62) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| Iodide SCHEMBL31463336 | 0.88 | PDGFRB (0.62) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL3995725 | 0.81 | RAB9A (0.52) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL27836844 | 0.80 | RAB9A (0.62) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| Cyclohexylamine SCHEMBL7802676 | 0.78 | RAB9A (0.54) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL372557 | 0.77 | KMT2A (0.53) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 | |
| SCHEMBL5717723 | 0.76 | RAB9A (0.75) | RAB9APDGFRBPDGFRAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101111475-B | Antiviral compounds and methods | BIOTRON LTD | 2012-09-05 | — | — | CN | disclosed |