Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 17/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.50 |
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1639079 | 0.84 | PIK3CB (0.60) | PIK3CBPIK3CAPIK3CDPIK3CGKCNH2 | |
| SCHEMBL27889939 | 0.84 | PRKDC (0.57) | PIK3CBPIK3CAPIK3CDPIK3CGPRKDC | |
| SCHEMBL24714319 | 0.83 | PIK3CB (0.71) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL28095991 | 0.82 | PIK3CB (0.48) | PIK3CBPIK3CAPIK3CDPIK3CGPRKDC | |
| SCHEMBL28946196 | 0.82 | PIK3CA (0.50) | PIK3CBPIK3CAPIK3CDPIK3CGPRKDC | |
| SCHEMBL1637732 | 0.79 | PIK3CB (0.56) | PIK3CBPIK3CAPIK3CDPIK3CGPRKDC | |
| SCHEMBL1639091 | 0.79 | PIK3CB (0.73) | PIK3CBPIK3CAPIK3CDPIK3CGKCNH2 | |
| SCHEMBL27873586 | 0.79 | PIK3CB (0.51) | PIK3CBPIK3CAPIK3CDPIK3CGPRKDC | |
| SCHEMBL1639036 | 0.79 | PIK3CB (0.70) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL27873650 | 0.78 | PIK3CB (0.73) | PIK3CBPIK3CAPIK3CDPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447657-A | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB | 2015-03-25 | — | — | CN | disclosed |
| CN-102712615-B | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2014-12-17 | — | — | CN | disclosed |
| CN-102712615-A | Chromenone Derivatives with Antitumor Activity | ASTRAZENECA AB | 2012-10-03 | — | — | CN | disclosed |