Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GCG | P01275 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | FABP4 | P15090 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27742353 | 0.85 | MAPK1 (0.55) | MAPK1CA1CA2NPC1RAB9A | |
| SCHEMBL27678805 | 0.84 | MAPK1 (0.57) | MAPK1CA1CA2NPC1RAB9A | |
| SCHEMBL2655859 | 0.82 | SMN1; SMN2 (0.44) | NPC1RAB9ASMN1; SMN2HPGDGCG | |
| SCHEMBL27742355 | 0.81 | MAPK1 (0.55) | MAPK1CA1CA2SMN1; SMN2CYP1A2 | |
| SCHEMBL9717451 | 0.78 | MAPK1 (0.85) | MAPK1CA1CA2HPGDCYP1A2 | |
| SCHEMBL5658746 | 0.75 | MAPK1 (0.72) | MAPK1CA1CA2SMN1; SMN2CYP1A2 | |
| SCHEMBL7735007 | 0.74 | MAPK1 (0.72) | MAPK1CA1CA2NPC1RAB9A | |
| SCHEMBL27658591 | 0.74 | MAPK1 (0.57) | MAPK1CA1CA2NPC1RAB9A | |
| SCHEMBL2973531 | 0.73 | MAPK1 (0.60) | MAPK1CA1CA2NPC1RAB9A | |
| SCHEMBL23794423 | 0.73 | MAPK1 (0.74) | MAPK1CA1CA2HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101309894-B | Glucagon receptor antagonists, preparation and therapeutic uses | LILLY CO ELI | 2012-10-03 | — | — | CN | disclosed |
| CN-101309894-A | Glucagon receptor antagonists, preparation and therapeutic uses | LILLY CO ELI (US) | 2008-11-19 | — | — | CN | disclosed |