Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.46 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27892837 | 0.86 | FYN (0.48) | FYNCSNK1DGSK3AGSK3BDYRK1A | |
| SCHEMBL27892827 | 0.85 | FYN (0.53) | FYNCSNK1DGSK3AGSK3BDYRK1A | |
| SCHEMBL27876162 | 0.81 | RPS6KA3 (0.44) | FYNMAPK10RPS6KA3BRAFCYP11B2 | |
| SCHEMBL16297083 | 0.75 | CYP1A1 (0.51) | FYNRPS6KB1MAPK10CYP11B2MAPK1 | |
| SCHEMBL1770160 | 0.75 | CSNK1D (0.43) | FYNCSNK1DGSK3AGSK3BDYRK1A | |
| SCHEMBL11178949 | 0.74 | CSNK1D (0.48) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL27876161 | 0.74 | PDE4B (0.56) | FYNCSNK1DGSK3AGSK3BDYRK1A | |
| SCHEMBL27876164 | 0.73 | DHPS (0.40) | BRAFCYP11B2IDO1CYP11B1 | |
| SCHEMBL8220816 | 0.72 | FYN (0.45) | FYNPDGFRBPDGFRAMAPK1KIT | |
| SCHEMBL15011871 | 0.72 | CYP1A1 (0.47) | RPS6KB1MAPK10CYP11B2MAPK1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102712589-A | Aryl-pyridine derivatives as aldosterone synthase inhibitors | NOVARTIS AG | 2012-10-03 | — | — | CN | claimed |
| CN-102712589-A | Aryl-pyridine derivatives as aldosterone synthase inhibitors | NOVARTIS AG | 2012-10-03 | — | — | CN | disclosed |