Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL278852 | 1.00 | TSHR (0.42) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL278793 | 1.00 | TSHR (0.42) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL278799 | 0.92 | TSHR (0.48) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL18378988 | 0.90 | TSHR (0.46) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL12047455 | 0.89 | TSHR (0.50) | TSHRCES1CYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL12047458 | 0.89 | TSHR (0.50) | TSHRCES1CYP3A4SMN1; SMN2MEN1 | |
| SCHEMBL19792791 | 0.87 | TSHR (0.50) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL17775385 | 0.87 | CES1 (0.52) | TSHRCES1CYP3A4ADRB2ADRB1 | |
| SCHEMBL14616850 | 0.84 | HSD17B10 (0.33) | CES1THRBALDH1A1 | |
| SCHEMBL14616849 | 0.84 | HSD17B10 (0.33) | CES1THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133707-B2 | Methods of preparing activated polymers having alpha nitrogen groups | ENZON PHARMACEUTICALS, INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-20070166808-A1 | Methods of preparing activated polymers having alpha nitrogen groups | BELROSE PHARMA INC. | 2007-07-19 | — | — | US | disclosed |