Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL405968 | 0.98 | TTR (0.47) | TTRKDM4EALDH1A1GAAL3MBTL1 | |
| Water SCHEMBL2789366 | 0.95 | TTR (0.45) | TTRKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL409177 | 0.84 | ALDH1A1 (0.51) | TTRALDH1A1PTPRCSRD5A2KMT2A | |
| SCHEMBL410454 | 0.82 | EGFR (0.46) | ALDH1A1L3MBTL1KMT2APOLBMEN1 | |
| SCHEMBL319590 | 0.82 | S1PR1 (0.52) | TTRPTPRCSRD5A2KMT2APOLB | |
| SCHEMBL272092 | 0.82 | TTR (0.56) | TTRKDM4EALDH1A1GAAL3MBTL1 | |
| SCHEMBL2773165 | 0.81 | TTR (0.46) | TTRKDM4EALDH1A1L3MBTL1PTPRC | |
| SCHEMBL3588665 | 0.80 | TTR (0.50) | TTRKDM4EALDH1A1GAAPTPRC | |
| SCHEMBL2770922 | 0.80 | TTR (0.42) | TTRPTPRCSRD5A2KMT2APOLB | |
| SCHEMBL2805441 | 0.79 | TTR (0.53) | TTRKDM4EGAAL3MBTL1PTPRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193126-A1 | OXADIAZOLE DIARYL COMPOUNDS | Merck Serono S.A. (CH) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009043890-A1 | OXADIAZOLE DIARYL COMPOUNDS | MERCK SERONO S.A. (CH) | 2009-04-09 | — | — | WO | disclosed |