Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.32 |
| ▸ | LIPC | P11150 | 7/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789091 | 0.87 | NMT1 (0.36) | DPP4DPP8DPP9DPP7NMT1 | |
| SCHEMBL2789311 | 0.87 | DPP4 (0.35) | DPP4DPP8DPP9DPP7NMT1 | |
| SCHEMBL2788340 | 0.86 | DPP4 (0.34) | DPP4DPP8DPP9DPP7NMT1 | |
| SCHEMBL2791424 | 0.85 | DPP4 (0.35) | DPP4DPP8DPP9DPP7NMT1 | |
| SCHEMBL2791066 | 0.85 | PROKR1 (0.39) | DPP4DPP9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2791994 | 0.84 | DPP4 (0.38) | DPP4DPP8DPP9DPP7NMT1 | |
| SCHEMBL2789653 | 0.83 | NPC1 (0.39) | PIK3CADPP4DPP8DPP9DPP7 | |
| SCHEMBL2791381 | 0.77 | PROKR1 (0.38) | CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL741570 | 0.77 | DPP4 (0.33) | DPP4DPP8DPP9DPP7NMT1 | |
| SCHEMBL741102 | 0.77 | NMT1 (0.34) | DPP4DPP8DPP9DPP7NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |