Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.67 |
| ▸ | TDO2 | P48775 | 2/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.41 |
| ▸ | TUBB | P07437 | 2/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7939316 | 0.84 | CYP11B1 (0.69) | CYP11B1CYP11B2TDO2TLR9TLR8 | |
| SCHEMBL1605727 | 0.84 | CYP11B1 (0.69) | CYP11B1CYP11B2TDO2TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL1606498 | 0.83 | CYP11B1 (0.68) | CYP11B1CYP11B2TDO2TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL1605472 | 0.83 | CYP11B1 (0.68) | CYP11B1CYP11B2TDO2TLR9TLR8 | |
| SCHEMBL2792363 | 0.80 | CYP11B2 (1.00) | CYP11B1CYP11B2TDO2TLR9TLR8 | |
| Hydrochloric Acid SCHEMBL1604935 | 0.79 | CYP11B2 (0.97) | CYP11B1CYP11B2TDO2TLR9TLR8 | |
| SCHEMBL1606346 | 0.79 | CYP11B1 (0.69) | CYP11B1CYP11B2TLR9TLR8TLR7 | |
| SCHEMBL1120862 | 0.79 | CYP11B1 (0.69) | CYP11B1CYP11B2TLR9TLR8TLR7 | |
| SCHEMBL1605619 | 0.79 | CYP11B1 (0.69) | CYP11B1CYP11B2TDO2TLR9NPY5R | |
| SCHEMBL1607053 | 0.79 | CYP11B1 (0.69) | CYP11B1CYP11B2TDO2TLR9NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |