Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 14/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.64 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | STAT1 | P42224 | 1/20 | 0.62 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.62 |
| ▸ | SDHB | P21912 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1199975 | 0.79 | KDM4E (1.00) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19805767 | 0.77 | SDHB (0.74) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19806030 | 0.77 | SDHB (0.86) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL29976120 | 0.76 | SDHB (1.00) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19805710 | 0.76 | SDHB (1.00) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19805808 | 0.74 | SDHB (1.00) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19806037 | 0.74 | SDHB (1.00) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19805798 | 0.72 | SDHB (0.73) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL19805786 | 0.71 | SDHB (1.00) | TP53MAPTGAATDP1SMN1; SMN2 | |
| SCHEMBL21019805 | 0.70 | SDHB (1.00) | TP53MAPTGAASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102993193-A | Use of nitrogen-3-isoxazolyl-3-4-thienyl-pyrimidyl sulfonyl propanamide derivative in preparing anti-tumor medicines | UNIV SICHUAN | 2013-03-27 | — | — | CN | claimed |
| CN-102993193-B | Use of nitrogen-3-isoxazolyl-3-4-thienyl-pyrimidyl sulfonyl propanamide derivative in preparing anti-tumor medicines | UNIV SICHUAN | 2015-05-27 | — | — | CN | disclosed |
| CN-102993193-A | Use of nitrogen-3-isoxazolyl-3-4-thienyl-pyrimidyl sulfonyl propanamide derivative in preparing anti-tumor medicines | UNIV SICHUAN | 2013-03-27 | — | — | CN | disclosed |