Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.43 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1623283 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1300566 | 0.80 | PIK3CA (0.52) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1621374 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL7898875 | 0.79 | PIK3CA (0.56) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4070882 | 0.79 | PIK3CA (0.50) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1862672 | 0.78 | PIK3CA (0.53) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1862201 | 0.77 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL1285075 | 0.77 | PIK3CA (0.46) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4437479 | 0.77 | PIK3CA (0.56) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1181732 | 0.77 | PIK3CA (0.46) | SMN1; SMN2PIK3CAPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102812167-A | Ligand-mediated covalent modification of proteins | AVILA THERAPEUTICS INC | 2012-12-05 | — | — | CN | disclosed |