⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27431300 | 0.69 | — | — | |
| SCHEMBL1263495 | 0.69 | — | — | |
| SCHEMBL10844214 | 0.69 | LMNA (0.39) | — | |
| SCHEMBL27209484 | 0.68 | — | — | |
| SCHEMBL7608197 | 0.67 | — | — | |
| SCHEMBL6764377 | 0.67 | — | — | |
| SCHEMBL9775013 | 0.67 | — | — | |
| SCHEMBL1264759 | 0.65 | — | — | |
| SCHEMBL10814740 | 0.65 | — | — | |
| SCHEMBL29043504 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104860980-B | It is a kind of to be used to synthesize intermediate of Ezetimibe and its preparation method and application | 上海弈柯莱生物医药科技有限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-105272954-B | A kind of preparation method of the ketone of 6 substituent methyl, 4 hydroxy tetrahydro pyrans 2 and its derivative | 上海弈柯莱生物医药科技有限公司 | 2017-10-13 | — | — | CN | disclosed |
| CN-104072398-B | A kind of method of synthesizing Ezetimibe | Henan Academy of SciencesChemistry Institute Co., Ltd. (CN) | 2016-02-03 | — | — | CN | disclosed |
| CN-104860980-A | Ezetimibe synthesis intermediate and preparation method and application thereof | NANJING ABIOCHEM BIOMEDICAL TECHNOLOGY CO LTD | 2015-08-26 | — | — | CN | disclosed |
| CN-104163783-A | Preparation method of ezetimibe | KAMP PHARMACEUTICALS CO LTD | 2014-11-26 | — | — | CN | disclosed |
| CN-104072398-A | Method for synthesizing ezetimibe | INST CHEMISTRY CO LTD HENAN ACADEMY OF SCIENCES | 2014-10-01 | — | — | CN | disclosed |
| CN-102477008-B | Method for synthesizing ezetimibe | UNIV SHENYANG PHARMACEUTICAL | 2014-05-21 | — | — | CN | disclosed |
| CN-103086938-A | Ezetimibe synthesis method | UNIV SHENYANG PHARMACEUTICAL | 2013-05-08 | — | — | CN | disclosed |
| CN-102477008-A | Synthesis method of ezetimibe | UNIV SHENYANG PHARMACEUTICAL | 2012-05-30 | — | — | CN | disclosed |