Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.33 |
| ▸ | CFD | P00746 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | NMT2 | O60551 | 1/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | PDE6A | P16499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790609 | 1.00 | PROKR1 (0.34) | PROKR1PIK3CDCFDDPP4MTOR | |
| SCHEMBL2791993 | 0.94 | PROKR1 (0.34) | PROKR1PIK3CDCFDDPP4MTOR | |
| SCHEMBL2792291 | 0.93 | DPP4 (0.33) | PROKR1CFDDPP4MTORPDE2A | |
| SCHEMBL2792294 | 0.93 | DPP4 (0.33) | PROKR1CFDDPP4MTORPDE2A | |
| SCHEMBL2813997 | 0.91 | PROKR1 (0.38) | PROKR1CFDDPP4PDE2APDE3A | |
| SCHEMBL7891283 | 0.90 | DPP4 (0.35) | PROKR1CFDDPP4BTK | |
| SCHEMBL7904628 | 0.90 | PROKR1 (0.40) | PROKR1CFDDPP4BTK | |
| SCHEMBL2790135 | 0.90 | PROKR1 (0.40) | PROKR1CFDDPP4BTK | |
| SCHEMBL7900932 | 0.90 | PROKR1 (0.40) | PROKR1CFDDPP4BTK | |
| SCHEMBL7900019 | 0.89 | PROKR1 (0.39) | PROKR1DPP4BTKNMT2NMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |