Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CFD | P00746 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 3/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2789936 | 0.93 | PROKR1 (0.37) | PROKR1DPP4ALDH1A1BTKTSHR | |
| SCHEMBL7891283 | 0.93 | DPP4 (0.35) | PROKR1DPP4BTKCFD | |
| SCHEMBL7900019 | 0.93 | PROKR1 (0.39) | PROKR1DPP4BTK | |
| SCHEMBL7904628 | 0.92 | PROKR1 (0.40) | PROKR1DPP4BTKCFD | |
| SCHEMBL2790135 | 0.92 | PROKR1 (0.40) | PROKR1DPP4BTKCFD | |
| SCHEMBL7900932 | 0.92 | PROKR1 (0.40) | PROKR1DPP4BTKCFD | |
| SCHEMBL2790609 | 0.91 | PROKR1 (0.34) | PROKR1DPP4BTKCFDPDE2A | |
| SCHEMBL2790607 | 0.91 | PROKR1 (0.34) | PROKR1DPP4BTKCFDPDE2A | |
| SCHEMBL2792291 | 0.91 | DPP4 (0.33) | PROKR1DPP4ALDH1A1BTKTSHR | |
| SCHEMBL2792294 | 0.91 | DPP4 (0.33) | PROKR1DPP4ALDH1A1BTKTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | claimed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |