Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 2-Chlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Chlorophenol SCHEMBL28880339 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL27384380 | 0.86 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL11241562 | 0.86 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL28880340 | 0.84 | ALDH1A1 (0.71) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL8961529 | 0.83 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL12279 | 0.83 | — | — | |
| 2-Chlorophenol SCHEMBL29354452 | 0.83 | — | — | |
| 2-Chlorophenol SCHEMBL27777880 | 0.82 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL673324 | 0.80 | ALDH1A1 (0.83) | ALDH1A1TSHRLMNACA12CA2 | |
| 2-Chlorophenol SCHEMBL7865189 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102391960-B | Arthrobacter chlorophenolicus L4 and application thereof | UNIV NANJING AGRICULTURAL | 2013-06-12 | — | — | CN | disclosed |