Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGAV | P06756 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27907103 | 0.84 | ALOX15 (0.33) | ALOX15SMYD3HSP90AA1IRAK4BRAF | |
| SCHEMBL15192577 | 0.81 | ALOX15 (0.38) | ALOX15SMYD3IRAK4BRAFKDM4E | |
| SCHEMBL572366 | 0.81 | ALOX15 (0.38) | ALOX15SMYD3IRAK4BRAFKDM4E | |
| SCHEMBL572659 | 0.81 | ACACB (0.41) | ALOX15HDAC1 | |
| SCHEMBL572658 | 0.81 | ACACB (0.41) | ALOX15HDAC1 | |
| SCHEMBL572882 | 0.75 | SMYD3 (0.34) | ALOX15SMYD3HSP90AA1IRAK4BRAF | |
| SCHEMBL572881 | 0.75 | SMYD3 (0.34) | ALOX15SMYD3HSP90AA1IRAK4BRAF | |
| SCHEMBL15199157 | 0.69 | ALOX15 (0.43) | ALOX15SMYD3HSP90AA1KDM4EGAA | |
| SCHEMBL572021 | 0.69 | CHRM3 (0.33) | ALOX15IRAK4BRAFKDM4EGAA | |
| SCHEMBL572022 | 0.69 | CHRM3 (0.33) | ALOX15IRAK4BRAFKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103168032-A | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase | AMGEN INC | 2013-06-19 | — | — | CN | disclosed |