Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.71 |
| ▸ | RAF1 | P04049 | 17/20 | 0.71 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890907 | 0.92 | BRAF (0.59) | BRAFRAF1EGFRERBB2KDR | |
| SCHEMBL28801011 | 0.92 | RAF1 (0.60) | BRAFRAF1EGFRERBB2KDR | |
| SCHEMBL28801394 | 0.86 | BRAF (0.67) | BRAFRAF1EGFRKDR | |
| SCHEMBL27986729 | 0.86 | BRAF (0.53) | BRAFRAF1EGFRERBB2KDR | |
| SCHEMBL27987180 | 0.85 | RAF1 (0.72) | BRAFRAF1EGFRERBB2 | |
| SCHEMBL27890908 | 0.85 | RAF1 (0.70) | BRAFRAF1EGFRERBB2KDR | |
| SCHEMBL15051752 | 0.83 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL27986782 | 0.83 | EGFR (0.61) | BRAFRAF1EGFRERBB2KDR | |
| SCHEMBL27907739 | 0.83 | RAF1 (0.66) | BRAFRAF1EGFRERBB2KDR | |
| SCHEMBL27986728 | 0.82 | SRC (0.67) | BRAFRAF1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102702116-B | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof | UNIV SOUTH CHINA TECH | 2014-12-31 | — | — | CN | claimed |
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | claimed |
| CN-102924387-B | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2015-07-01 | — | — | CN | disclosed |
| CN-102702116-B | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof | UNIV SOUTH CHINA TECH | 2014-12-31 | — | — | CN | disclosed |
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | disclosed |