Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.67 |
| ▸ | RAF1 | P04049 | 14/20 | 0.67 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | GAK | O14976 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27890908 | 0.88 | RAF1 (0.70) | BRAFRAF1RETKDREGFR | |
| SCHEMBL17845962 | 0.88 | RAF1 (0.59) | BRAFRAF1KDREGFR | |
| SCHEMBL27907693 | 0.86 | BRAF (0.71) | BRAFRAF1KDREGFR | |
| SCHEMBL27907697 | 0.86 | EGFR (0.62) | BRAFRAF1MEN1USP2LMNA | |
| SCHEMBL28801011 | 0.85 | RAF1 (0.60) | BRAFRAF1KDREGFR | |
| SCHEMBL27890907 | 0.85 | BRAF (0.59) | BRAFRAF1KDRMEN1USP2 | |
| SCHEMBL27987180 | 0.84 | RAF1 (0.72) | BRAFRAF1EGFR | |
| SCHEMBL27907718 | 0.82 | RAF1 (0.60) | BRAFRAF1KDREGFR | |
| SCHEMBL27986782 | 0.82 | EGFR (0.61) | BRAFRAF1KDREGFR | |
| SCHEMBL27907739 | 0.82 | RAF1 (0.66) | BRAFRAF1KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102702116-B | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof | UNIV SOUTH CHINA TECH | 2014-12-31 | — | — | CN | disclosed |
| CN-102702116-B | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof | UNIV SOUTH CHINA TECH | 2014-12-31 | — | — | CN | disclosed |
| CN-102702116-A | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof | UNIV SOUTH CHINA TECH | 2012-10-03 | — | — | CN | disclosed |
| CN-102702116-A | 4-(3-chloro-4-methoxylanilino)-6-(3-amidophenyl)quinazoline compound or pharmaceutically-acceptable salt thereof and preparation methods and applications thereof | UNIV SOUTH CHINA TECH | 2012-10-03 | — | — | CN | disclosed |