Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12274916 | 0.81 | MEN1 (0.53) | EPHB4IGF1RMAPTGAASYK | |
| SCHEMBL27987181 | 0.81 | BRAF (0.50) | MAPTGAASYKPTK2BRAF | |
| SCHEMBL12275237 | 0.79 | PAK1 (0.58) | PTK2PAK1LRRK2FLT3 | |
| SCHEMBL27907697 | 0.79 | EGFR (0.62) | ABCG2BRAFALDH1A1MEN1LMNA | |
| SCHEMBL1197401 | 0.78 | SYK (0.72) | ABCG2SYK | |
| SCHEMBL12274826 | 0.74 | FLT3 (0.52) | ABCG2SYKPTK2BRAFPAK1 | |
| SCHEMBL12274361 | 0.72 | MEN1 (0.56) | ABCG2SYKBRAFNPC1RAB9A | |
| SCHEMBL2205050 | 0.70 | KDM4E (0.52) | ABCG2EPHB4IGF1RMAPTGAA | |
| SCHEMBL1667296 | 0.69 | ABCG2 (0.60) | ABCG2MAPTALDH1A1MEN1LMNA | |
| SCHEMBL12273795 | 0.69 | SYK (0.54) | SYKBRAFNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | disclosed |