Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | USP2 | O75604 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | BRAF | P15056 | 11/20 | 0.57 |
| ▸ | RAF1 | P04049 | 10/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28801394 | 0.86 | BRAF (0.67) | EGFRCYP1A2HSD17B10CYP3A4CLK4 | |
| SCHEMBL27890908 | 0.85 | RAF1 (0.70) | EGFRABCG2BRAFRAF1ERBB2 | |
| SCHEMBL28801011 | 0.82 | RAF1 (0.60) | EGFRBRAFRAF1ERBB2 | |
| SCHEMBL27890907 | 0.82 | BRAF (0.59) | EGFRCYP1A2HSD17B10CYP3A4CLK4 | |
| SCHEMBL27907718 | 0.81 | RAF1 (0.60) | EGFRALDH1A1BRAFRAF1ERBB2 | |
| SCHEMBL27907693 | 0.81 | BRAF (0.71) | EGFRBRAFRAF1ERBB2 | |
| SCHEMBL27987180 | 0.81 | RAF1 (0.72) | EGFRABCG2BRAFRAF1ERBB2 | |
| SCHEMBL27986782 | 0.79 | EGFR (0.61) | EGFRBRAFRAF1ERBB2ERBB4 | |
| SCHEMBL27907705 | 0.79 | MAP4K1 (0.49) | ABCG2ALDH1A1LMNABRAFMEN1 | |
| SCHEMBL17845962 | 0.78 | RAF1 (0.59) | EGFRABCG2BRAFRAF1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | claimed |
| CN-102924387-B | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2015-07-01 | — | — | CN | disclosed |
| CN-102924387-A | 4-(3-chloro-4-methoxyanilino)-6-(3,4-substituted phenyl)quinazoline and salts thereof, preparation method and applications | HUANG WEIYAN | 2013-02-13 | — | — | CN | disclosed |