Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | PREP | P48147 | 3/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27891373 | 1.00 | AADAT (0.51) | AADATACE2CTSKPREPTMEM97 | |
| SCHEMBL953139 | 0.86 | AADAT (0.52) | AADATACE2PREPTMEM97SIGMAR1 | |
| SCHEMBL953138 | 0.86 | AADAT (0.52) | AADATACE2PREPTMEM97SIGMAR1 | |
| SCHEMBL18850754 | 0.84 | HCRTR1 (0.53) | AADATACE2PREPTMEM97SIGMAR1 | |
| SCHEMBL475407 | 0.82 | AADAT (0.51) | AADATACE2CTSKPREPTMEM97 | |
| SCHEMBL475406 | 0.82 | AADAT (0.51) | AADATACE2CTSKPREPTMEM97 | |
| SCHEMBL27891374 | 0.82 | AADAT (0.49) | AADATACE2PREPTMEM97SIGMAR1 | |
| SCHEMBL952909 | 0.78 | PREP (0.50) | AADATACE2PREPTMEM97SIGMAR1 | |
| SCHEMBL952907 | 0.78 | PREP (0.50) | AADATACE2PREPTMEM97SIGMAR1 | |
| SCHEMBL4220121 | 0.77 | PREP (0.50) | AADATACE2PREPTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101868457-B | (3-hydroxy-4-amino-but-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for use in therapy | COMENTIS INC | 2013-02-13 | — | — | CN | disclosed |