Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31626148 | 0.87 | JAK1 (0.42) | ACHEJAK2JAK1PIK3CDHTR6 | |
| SCHEMBL14797959 | 0.87 | JAK1 (0.42) | ACHEJAK2JAK1PIK3CDHTR6 | |
| SCHEMBL15711178 | 0.83 | JAK2 (0.49) | JAK2JAK1PIK3CDHTR6EGFR | |
| SCHEMBL15171143 | 0.83 | JAK2 (0.49) | JAK2JAK1PIK3CDHTR6EGFR | |
| SCHEMBL15171260 | 0.81 | HTR6 (0.46) | BCHEJAK2JAK1HTR6EGFR | |
| SCHEMBL16341186 | 0.81 | HTR6 (0.46) | BCHEJAK2JAK1HTR6EGFR | |
| SCHEMBL20480936 | 0.81 | JAK1 (0.39) | KMT2AACHEJAK2JAK1HTR6 | |
| SCHEMBL20480742 | 0.80 | PIK3CD (0.38) | NPSR1KDM4EMAPTTP53TSHR | |
| SCHEMBL16143648 | 0.80 | PIK3CD (0.38) | NPSR1KDM4EMAPTTP53TSHR | |
| SCHEMBL25167958 | 0.80 | NPSR1 (0.41) | NPSR1KDM4EMAPTTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958513-A | 6-Hydroxypurine derivative hydrochloride | ONO PHARMACEUTICAL CO | 2014-07-30 | — | — | CN | disclosed |
| CN-102918040-A | Purinone derivative | ONO PHARMACEUTICAL CO | 2013-02-06 | — | — | CN | disclosed |