Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | VCP | P55072 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | LDHB | P07195 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL27927102 | 0.91 | ATR (0.49) | FGFR2FLT3VCPATRKDR | |
| SCHEMBL1640841 | 0.91 | FGFR2 (0.69) | FGFR2FLT3VCPEGFRATR | |
| SCHEMBL1640855 | 0.82 | FGFR2 (0.50) | FGFR2FLT3VCPEGFRATR | |
| SCHEMBL1642784 | 0.82 | FGFR2 (0.54) | FGFR2FLT3VCPEGFRATR | |
| Akn-028 SCHEMBL31060922 | 0.74 | FGFR2 (1.00) | FGFR2FLT3EGFRATRKDR | |
| SCHEMBL1642794 | 0.74 | FGFR2 (0.72) | FGFR2FLT3EGFRATRFLT1 | |
| Akn-028 SCHEMBL1642669 | 0.74 | FGFR2 (1.00) | FGFR2FLT3EGFRATRKDR | |
| SCHEMBL1642894 | 0.73 | EGFR (0.56) | FGFR2FLT3VCPEGFRKDR | |
| SCHEMBL1642621 | 0.67 | FGFR2 (0.81) | FGFR2FLT3EGFRATRKDR | |
| SCHEMBL1642507 | 0.66 | FGFR2 (0.72) | FGFR2FLT3EGFRATRPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970418-B | Pyrazine derivative and its uses as protein kinase inhibitor | AKINION PHARMACEUTICALS AB | 2013-07-03 | — | — | CN | claimed |