Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27893710 | 0.86 | PARP1 (0.36) | SMN1; SMN2MEN1KMT2ACNR1PARP1 | |
| SCHEMBL27893711 | 0.86 | PARP1 (0.36) | SMN1; SMN2MEN1KMT2ACNR1PARP1 | |
| SCHEMBL27808388 | 0.82 | PARP1 (0.39) | SMN1; SMN2MEN1KMT2APARP1CA1 | |
| SCHEMBL27911496 | 0.79 | DGAT1 (0.34) | SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL28039485 | 0.75 | PARP1 (0.40) | SMN1; SMN2MEN1KMT2APARP1CA1 | |
| SCHEMBL2175561 | 0.72 | SMN1; SMN2 (0.36) | SMN1; SMN2MEN1KMT2APARP1CA1 | |
| SCHEMBL27541465 | 0.71 | PARP15 (0.46) | PARP1TAAR1GLAPARP15PARP14 | |
| SCHEMBL243147 | 0.70 | AAK1 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL27911532 | 0.70 | NPC1 (0.40) | SMN1; SMN2MEN1KMT2ACA1CA2 | |
| SCHEMBL4434733 | 0.70 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2APARP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102985412-A | 3-amino-5,6-dihydro-1h-pyrazin-2-one derivatives useful for the treatement of alzheimer's disease and other forms of dementia | JANSSEN PHARMACEUTICA NV | 2013-03-20 | — | — | CN | disclosed |