Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | CCND1 | P24385 | 4/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29384135 | 0.93 | CDK4 (0.56) | CDK4CCND1NOTUMCA12CA9 | |
| SCHEMBL29812 | 0.93 | CDK4 (0.56) | CDK4CCND1NOTUMCA12CA9 | |
| Bromide SCHEMBL6480413 | 0.91 | CDK4 (0.54) | CDK4CCND1NOTUMCA12CA9 | |
| Hydrochloric Acid SCHEMBL30610362 | 0.91 | CDK4 (0.54) | CDK4CCND1NOTUMCA12CA9 | |
| Bromide SCHEMBL31591097 | 0.91 | CDK4 (0.54) | CDK4CCND1NOTUMCA12CA9 | |
| Hydrochloric Acid SCHEMBL1356443 | 0.91 | CDK4 (0.54) | CDK4CCND1NOTUMCA12CA9 | |
| Dimethylamine SCHEMBL3332471 | 0.86 | CDK4 (0.50) | CDK4CCND1NOTUMCA12CA9 | |
| SCHEMBL3867839 | 0.85 | NOTUM (0.48) | CDK4CCND1NOTUMCA12CA9 | |
| Acetic Acid SCHEMBL10698023 | 0.85 | NOTUM (0.58) | CDK4CCND1NOTUMCA12CA9 | |
| SCHEMBL3117662 | 0.85 | NOTUM (0.53) | CDK4CCND1NOTUMCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105753858-B | Heterocyclic compound and p27Kip1Decomposing inhibitor | ASKA制药株式会社 | 2019-04-30 | — | — | CN | disclosed |
| CN-105753858-A | Heterocyclic compound and p27Kip1 degradation inhibitor | ASKA制药株式会社 | 2016-07-13 | — | — | CN | disclosed |
| CN-102985405-B | Heterocyclic compounds and p27Kip1Decomposition inhibitor | ASKA制药株式会社 | 2016-07-06 | — | — | CN | disclosed |
| CN-102985405-A | Heterocyclic compounds and p27Kip1Decomposition inhibitor | ASKA PHARM CO LTD | 2013-03-20 | — | — | CN | disclosed |