Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28225088 | 0.81 | TSHR (0.48) | TSHRPOLBSRCHPGDKDM4E | |
| SCHEMBL27318105 | 0.75 | TSHR (0.48) | TSHRPOLBSRCHPGDKDM4E | |
| SCHEMBL3556535 | 0.74 | TSHR (0.52) | TSHRPOLBSRCHPGDKDM4E | |
| SCHEMBL13479807 | 0.74 | TSHR (0.52) | TSHRPOLBSRCHPGDKDM4E | |
| SCHEMBL10776992 | 0.72 | TSHR (0.50) | TSHRPOLBSRCHPGDKDM4E | |
| SCHEMBL28844027 | 0.72 | TDP1 (0.44) | TSHRPOLBHPGDKDM4ETDP1 | |
| SCHEMBL28777 | 0.72 | MLYCD (0.54) | TSHRHPGDKDM4ERAB9AALDH1A1 | |
| SCHEMBL11853707 | 0.71 | HPGD (0.39) | TSHRHPGDKDM4ETDP1SMN1; SMN2 | |
| SCHEMBL10841502 | 0.71 | TSHR (0.48) | TSHRPOLBSRCHPGDKDM4E | |
| SCHEMBL28441499 | 0.71 | TSHR (0.54) | TSHRPOLBSRCHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103209979-A | Therapeutic agent 976 | ASTRAZENECA AB | 2013-07-17 | — | — | CN | disclosed |