Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.50 |
| ▸ | TUBB | P07437 | 2/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275354 | 1.00 | LRRK2 (0.58) | LRRK2PDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL275355 | 1.00 | LRRK2 (0.58) | LRRK2PDGFRBTUBB4ATUBBTUBA3C | |
| SCHEMBL13929117 | 0.91 | PDGFRB (0.60) | LRRK2PDGFRBPLK4PLK1KDR | |
| SCHEMBL4723150 | 0.91 | PDGFRB (0.60) | LRRK2PDGFRBPLK4PLK1KDR | |
| SCHEMBL29443853 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL250593 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL250592 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8205160 | 0.90 | LRRK2 (0.65) | LRRK2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14674926 | 0.90 | LRRK2 (0.73) | LRRK2PDGFRBPSEN1PSEN2APH1B | |
| SCHEMBL14674927 | 0.90 | LRRK2 (0.73) | LRRK2PDGFRBPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742121-B2 | Process for the preparation of small molecule inhibitors of MDM2 and intermediates used therein | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-06-03 | — | — | US | claimed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | claimed |
| US-20130030173-A1 | PROCESS FOR THE PREPARATION OF SMALL MOLECULE INHIBITORS OF MDM2 AND INTERMEDIATES USED THEREIN | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-01-31 | — | — | US | claimed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-8877946-B2 | Benzylidene-indolinone compounds and their medical use | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-11-04 | — | — | US | disclosed |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2013-02-07 | — | — | US | disclosed |
| US-8217051-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-07-10 | — | — | US | disclosed |
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| US-8134001-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-03-13 | — | — | US | disclosed |
| EP-2229396-B1 | SPIROINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | disclosed |
| US-20100210674-A1 | Spiroindolinone Derivatives | HOFFMANN-LA ROCHE INC. | 2010-08-19 | — | — | US | disclosed |
| US-7638548-B2 | Spiroindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-12-29 | — | — | US | disclosed |
| WO-2009077357-A1 | SPIROINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
| US-20090156610-A1 | Spiroindolinone Derivatives | DING QINGJIE | 2009-06-18 | — | — | US | disclosed |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | LIU JIN-JUN | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156610-A1 | Spiroindolinone Derivatives | SDHA, AR, XPOT | LRRK2 1100/4885PDGFRB 1789/4885TUBB4A 414/4885 |
| US-20130035364-A1 | BENZYLIDENE-INDOLINONE COMPOUNDS AND THEIR MEDICAL USE | ERBB2, ABL1, IGF1R | LRRK2 19/4885PDGFRB 11/4885TUBB4A 311/4885 |
| US-20100210674-A1 | Spiroindolinone Derivatives | RCC2, PKD1, SIK2 | LRRK2 870/4885PDGFRB 1738/4885TUBB4A 412/4885 |
| US-20130030173-A1 | PROCESS FOR THE PREPARATION OF SMALL MOLECULE INHIBITORS OF MDM2 AND INTERMEDIATES USED THEREIN | TP53, MDM2, CDKN1A | LRRK2 963/4885PDGFRB 2992/4885TUBB4A 2763/4885 |
| US-20080114013-A1 | SPIROINDOLINONE DERIVATIVES | RB1, XPOT, PDK2 | LRRK2 267/4885PDGFRB 1904/4885TUBB4A 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.