Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 13/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PRKCG | P05129 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | PRKX | P51817 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791408 | 0.89 | NAMPT (0.65) | NAMPTROCK2ROCK1 | |
| SCHEMBL2793965 | 0.87 | NAMPT (0.67) | NAMPTROCK2ROCK1 | |
| SCHEMBL2794381 | 0.86 | ROCK2 (0.64) | NAMPTROCK2ROCK1HTTJAK2 | |
| SCHEMBL2793411 | 0.86 | ROCK2 (0.57) | NAMPTROCK2ROCK1HTTJAK2 | |
| SCHEMBL2794930 | 0.86 | NAMPT (0.58) | NAMPTROCK2ROCK1HTTJAK2 | |
| SCHEMBL2795287 | 0.85 | NAMPT (0.59) | NAMPTROCK2ROCK1JAK2TYK2 | |
| SCHEMBL2795774 | 0.85 | POLB (0.63) | NAMPTROCK2ROCK1HTTJAK2 | |
| SCHEMBL2792854 | 0.83 | ROCK2 (0.60) | NAMPTROCK2ROCK1HTTJAK2 | |
| SCHEMBL3502319 | 0.83 | NAMPT (0.60) | NAMPTROCK2ROCK1HTTJAK2 | |
| SCHEMBL3502315 | 0.83 | NAMPT (0.60) | NAMPTROCK2ROCK1HTTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2010-07-01 | — | — | US | disclosed |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | DEVGEN NV (BE) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168102-A9 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | NAMPT 1420/4885ROCK2 528/4885ROCK1 414/4885 |
| US-20090118283-A1 | Amide Derivatives as Kinase Inhibitors | MAP3K1, CDK1, CDK2 | NAMPT 1420/4885ROCK2 528/4885ROCK1 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.