Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622827 | 1.00 | LMNA (0.64) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL10767645 | 0.86 | LMNA (0.48) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL5949941 | 0.84 | LMNA (0.78) | LMNAPTGS1ADRB2ADRB1CYP2D6 | |
| SCHEMBL159889 | 0.83 | MAPT (0.43) | LMNAPTGS1MAOACYP2D6MAPT | |
| SCHEMBL10785452 | 0.83 | LMNA (0.42) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL11555241 | 0.79 | PTGS1 (0.40) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL17133871 | 0.79 | PTGS1 (0.40) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL27982479 | 0.79 | PTGS1 (0.40) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL1618880 | 0.78 | LMNA (1.00) | LMNAPTGS1MAOAADRB2ADRB1 | |
| SCHEMBL50453 | 0.78 | LMNA (1.00) | LMNAPTGS1MAOAADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103497114-A | NMDA receptor antagonists for neuroprotection | UNIV EMORY | 2014-01-08 | — | — | CN | disclosed |
| CN-103058957-A | NMDA receptor antagonists for neuroprotection | UNIV EMORY | 2013-04-24 | — | — | CN | disclosed |