Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.41 |
| ▸ | FLT3 | P36888 | 12/20 | 0.41 |
| ▸ | TYK2 | P29597 | 12/20 | 0.41 |
| ▸ | JAK1 | P23458 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | LYN | P07948 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27917237 | 0.91 | JAK2 (0.40) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL27935904 | 0.80 | JAK2 (0.43) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL28805477 | 0.74 | JAK2 (0.42) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL29754302 | 0.74 | JAK2 (0.49) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL4562362 | 0.74 | JAK2 (0.49) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL29754279 | 0.73 | JAK2 (0.51) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL22545997 | 0.73 | JAK2 (0.51) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL28805482 | 0.73 | JAK2 (0.41) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL22545874 | 0.70 | JAK2 (0.46) | JAK2FLT3TYK2JAK1JAK3 | |
| SCHEMBL29754337 | 0.70 | JAK2 (0.46) | JAK2FLT3TYK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | claimed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |