Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 14/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.41 |
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 6/20 | 0.39 |
| ▸ | FLT3 | P36888 | 6/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27917227 | 0.88 | JAK2 (0.43) | JAK2JAK3TYK2FLT3JAK1 | |
| SCHEMBL28805476 | 0.88 | JAK2 (0.40) | JAK2JAK3CDK4CDK6PIK3CD | |
| SCHEMBL28807349 | 0.85 | JAK2 (0.44) | JAK2JAK3TYK2FLT3JAK1 | |
| SCHEMBL28805477 | 0.83 | JAK2 (0.42) | JAK2JAK3CDK4CDK6PIK3CD | |
| SCHEMBL27967482 | 0.77 | JAK1 (0.40) | JAK2JAK3TYK2JAK1 | |
| SCHEMBL27935904 | 0.75 | JAK2 (0.43) | JAK2JAK3TYK2FLT3JAK1 | |
| SCHEMBL27917233 | 0.73 | JAK2 (0.41) | JAK2JAK3CDK4CDK6TYK2 | |
| SCHEMBL27917420 | 0.73 | AXL (0.40) | JAK2JAK3CDK4CDK6PIK3CD | |
| SCHEMBL4559900 | 0.72 | JAK3 (0.45) | JAK2JAK3TYK2JAK1HDAC1 | |
| SCHEMBL4561735 | 0.71 | JAK2 (0.44) | JAK2JAK3TYK2JAK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | claimed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |