Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 12/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.48 |
| ▸ | NQO2 | P16083 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686377 | 1.00 | LMNA (0.62) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL1686373 | 1.00 | LMNA (0.62) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL1686424 | 1.00 | LMNA (0.62) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL1686422 | 1.00 | LMNA (0.62) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL1686374 | 1.00 | LMNA (0.62) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL2979829 | 0.87 | LMNA (0.48) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL2979831 | 0.87 | LMNA (0.48) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL2979826 | 0.87 | LMNA (0.48) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL2983063 | 0.85 | LMNA (0.58) | LMNAGAAMTNR1AMTNR1BNQO2 | |
| SCHEMBL2976822 | 0.85 | LMNA (0.58) | LMNAGAAMTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185530-A1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon (NL) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016241-A1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. ORGANON (NL) | 2009-02-05 | — | — | WO | disclosed |