SCHEMBL27923398

SCHEMBL27923398

CC[Si](C#Cc1cccc2cc3ccccc3cc12)(C(C)C)C(C)C

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACACB O00763 1/20 0.33
GRM5 P41594 1/20 0.31
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30
HTR2A P28223 1/20 0.30
HTR2C P28335 1/20 0.30
HTR2B P41595 1/20 0.30
CHAT P28329 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28001806 0.84 HRH3 (0.31) ACACBHTR2AHTR2CHTR2B
SCHEMBL28476001 0.83
SCHEMBL27814779 0.82 ALDH1A1 (0.33) ACACBGRM5KDM4EALDH1A1GAA
SCHEMBL650997 0.82 KDM4E (0.32) KDM4EHTR2AHTR2CHTR2B
SCHEMBL27820573 0.82 P2RY6 (0.34) GRM5KDM4EALDH1A1GAAHTR2A
SCHEMBL497591 0.81 GRM5 (0.33) GRM5KDM4EALDH1A1GAACHAT
SCHEMBL15756938 0.81 P2RY6 (0.34) GRM5KDM4EALDH1A1GAAHTR2A
SCHEMBL28433044 0.81 GRM5 (0.33) GRM5KDM4EALDH1A1GAACHAT
SCHEMBL15667289 0.80 ALDH1A1 (0.31) ACACBGRM5KDM4EALDH1A1GAA
SCHEMBL649343 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103154007-A Anthra[2,3-b:7,6b']dithiophene derivatives and their use as organic semiconductors MERCK PATENT GMBH 2013-06-12 CN disclosed