Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 13/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15022322 | 0.78 | CSNK1D (0.52) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL15022080 | 0.75 | PDE10A (0.49) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL27924982 | 0.75 | MAPK13 (0.46) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL15022065 | 0.75 | PDE10A (0.49) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL27907019 | 0.73 | MAPK14 (0.56) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL15022316 | 0.67 | MAPK13 (0.62) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL5258671 | 0.67 | MAPK13 (0.71) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL27924978 | 0.66 | MAPK13 (0.61) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 | |
| SCHEMBL15023023 | 0.66 | PDE10A (0.52) | PDE10ALGALS3PDE4D | |
| SCHEMBL5258392 | 0.66 | MAPK13 (0.74) | CSNK1DMAPK14MAPK13CSNK1EMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103159738-B | The heteroaryl aroma compounds of alkynyl bridging and application thereof | 上海泓博智源医药股份有限公司 | 2016-09-07 | — | — | CN | disclosed |
| CN-103159738-A | Mixed aromatic compound of alkynyl bridging and application thereof | SHANGHAI HONGBO ZHIYUAN MEDICAL TECHNOLOGY CO LTD | 2013-06-19 | — | — | CN | disclosed |