Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Anastrozole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 19/20 | 1.00 |
| ▸ | UGT1A4 | P22310 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | STS | P08842 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anastrozole SCHEMBL177942 | 1.00 | CYP19A1 (1.00) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL9726 | 1.00 | CYP19A1 (1.00) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL28771766 | 0.99 | CYP19A1 (0.97) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL5917785 | 0.99 | CYP19A1 (0.97) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL3172308 | 0.99 | CYP19A1 (0.97) | CYP19A1UGT1A4PDE4DESR1STS | |
| SCHEMBL10324455 | 0.96 | CYP19A1 (0.92) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL13323739 | 0.95 | CYP19A1 (0.90) | CYP19A1UGT1A4PDE4DESR1STS | |
| SCHEMBL8059026 | 0.93 | CYP19A1 (0.87) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL354747 | 0.92 | CYP19A1 (0.85) | CYP19A1UGT1A4PDE4DESR1STS | |
| SCHEMBL12908863 | 0.92 | CYP19A1 (0.85) | CYP19A1UGT1A4PDE4DESR1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104610176-A | Anastrozole as well as novel crystal form, preparation method and application of monohydrate thereof | HANGZHOU EAST CHINA PHARMACEUTICAL GROUP NEW DRUG RES INST CO LTD | 2015-05-13 | — | — | CN | claimed |
| CN-103450099-B | Anastrozole and new crystal form of monohydrate thereof, preparation and application | HANGZHOU EAST CHINA PHARMACEUTICAL GROUP NEW DRUG RES INST CO LTD | 2015-03-25 | — | — | CN | claimed |
| CN-103450099-A | Anastrozole and new crystal form of monohydrate thereof, preparation and application | HANGZHOU HUADONG MEDICINE GROUP BIOLOGY ENG RES CO LTD | 2013-12-18 | — | — | CN | claimed |
| CN-104628662-A | Anastrozole and novel crystal form, preparation method and application of monohydrate of anastrozole | HANGZHOU EAST CHINA PHARMACEUTICAL GROUP NEW DRUG RES INST CO LTD | 2015-05-20 | — | — | CN | disclosed |
| CN-104610176-A | Anastrozole as well as novel crystal form, preparation method and application of monohydrate thereof | HANGZHOU EAST CHINA PHARMACEUTICAL GROUP NEW DRUG RES INST CO LTD | 2015-05-13 | — | — | CN | disclosed |
| CN-103450099-B | Anastrozole and new crystal form of monohydrate thereof, preparation and application | HANGZHOU EAST CHINA PHARMACEUTICAL GROUP NEW DRUG RES INST CO LTD | 2015-03-25 | — | — | CN | disclosed |
| CN-103450099-A | Anastrozole and new crystal form of monohydrate thereof, preparation and application | HANGZHOU HUADONG MEDICINE GROUP BIOLOGY ENG RES CO LTD | 2013-12-18 | — | — | CN | disclosed |