Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Anastrozole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 19/20 | 0.97 |
| ▸ | UGT1A4 | P22310 | 1/20 | 0.97 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.97 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | STS | P08842 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anastrozole SCHEMBL27927481 | 0.99 | CYP19A1 (1.00) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL9726 | 0.99 | CYP19A1 (1.00) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL177942 | 0.99 | CYP19A1 (1.00) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL5917785 | 0.97 | CYP19A1 (0.97) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL28771766 | 0.97 | CYP19A1 (0.97) | CYP19A1UGT1A4PDE4DESR1STS | |
| SCHEMBL10324455 | 0.94 | CYP19A1 (0.92) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL13323739 | 0.93 | CYP19A1 (0.90) | CYP19A1UGT1A4PDE4DESR1STS | |
| SCHEMBL8059026 | 0.92 | CYP19A1 (0.87) | CYP19A1UGT1A4PDE4DESR1STS | |
| Hydrochloric Acid SCHEMBL8058748 | 0.91 | CYP19A1 (0.81) | CYP19A1UGT1A4PDE4DESR1STS | |
| Anastrozole SCHEMBL354747 | 0.91 | CYP19A1 (0.85) | CYP19A1UGT1A4PDE4DESR1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060035950-A1 | Novel processes for preparing substantially pure anastrozole | CHEMAGIS LTD. (IL) | 2006-02-16 | — | — | US | claimed |
| EP-2024343-B1 | PROCESS FOR PURIFICATION OF ANASTROZOLE | SYNTHON BV (NL) | 2015-09-09 | — | — | EP | disclosed |
| CN-101568526-B | Process for purification of anastrozole | SYNTHON BV | 2013-03-06 | — | — | CN | disclosed |
| US-7655806-B2 | Process for purification of anastrozole | SYNTHON BV (NL) | 2010-02-02 | — | — | US | disclosed |
| CN-101568526-A | Process for purification of anastrozole | SYNTHON BV (NL) | 2009-10-28 | — | — | CN | disclosed |
| EP-2024343-A2 | PROCESS FOR PURIFICATION OF ANASTROZOLE | Synthon B.V. (NL) | 2009-02-18 | — | — | EP | disclosed |
| WO-2009010991-A2 | PURIFICATION PROCESS TO PREPARE HIGHLY PURE ANASTROZOLE | IND-SWIFT LABORATORIES LIMITED (IN) | 2009-01-22 | — | — | WO | disclosed |
| US-20070281982-A1 | PROCESS FOR PURIFICATION OF ANASTROZOLE | SYNTHON BV (NL) | 2007-12-06 | — | — | US | disclosed |
| WO-2007134846-A2 | PROCESS FOR PURIFICATION OF ANASTROZOLE | SYNTHON B.V. (NL) | 2007-11-29 | — | — | WO | disclosed |
| US-20060035950-A1 | Novel processes for preparing substantially pure anastrozole | CHEMAGIS LTD. (IL) | 2006-02-16 | — | — | US | disclosed |
| WO-2005105762-A1 | IMPROVED PROCESS FOR THE PREPARATION OF HIGH PURITY ANASTROZOLE | NATCO PHARMA LIMITED (IN) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281982-A1 | PROCESS FOR PURIFICATION OF ANASTROZOLE | CYP19A1, HSD17B11, ADH1A | CYP19A1 1/4885UGT1A4 254/4885PDE4D 1560/4885 |
| US-20060035950-A1 | Novel processes for preparing substantially pure anastrozole | CYP19A1, CYP11A1, CYP4B1 | CYP19A1 1/4885UGT1A4 1143/4885PDE4D 950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.