Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SREBF2 | Q12772 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL99513 | 0.83 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL15398600 | 0.71 | ECE1 (0.40) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| Trifluoroacetic Acid SCHEMBL29540593 | 0.70 | ROCK1 (0.58) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| Trifluoroacetic Acid SCHEMBL99512 | 0.70 | ROCK1 (0.58) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL98793 | 0.64 | HDAC6 (0.42) | RAB9ASMN1; SMN2NPC1KDM4EKMT2A | |
| SCHEMBL30279818 | 0.63 | SMN1; SMN2 (0.65) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL21479755 | 0.63 | SMN1; SMN2 (0.65) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL98272 | 0.62 | ROCK1 (0.62) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL4082160 | 0.62 | HDAC6 (0.39) | RAB9ASMN1; SMN2NPC1KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL15398599 | 0.62 | KDM4E (0.42) | RAB9ASMN1; SMN2NPC1CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103214484-B | Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine | 因塞特控股公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103214483-B | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2014-12-17 | — | — | CN | disclosed |
| CN-103254190-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-08-21 | — | — | CN | disclosed |
| CN-103214484-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP A DELAWARE CORP | 2013-07-24 | — | — | CN | disclosed |
| CN-103214483-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-07-24 | — | — | CN | disclosed |