Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25524181 | 0.82 | RPS6KA5 (0.38) | RPS6KA5LATS1PRMT5WDR77HTR2A | |
| SCHEMBL22308332 | 0.79 | LATS1 (0.38) | RPS6KA5LATS1PRMT5WDR77HTR2A | |
| SCHEMBL27942012 | 0.79 | RPS6KA5 (0.35) | RPS6KA5NTRK1 | |
| SCHEMBL2611037 | 0.78 | RPS6KA5 (0.42) | RPS6KA5LATS1PRMT5WDR77NTRK1 | |
| SCHEMBL1797434 | 0.68 | RPS6KA5 (0.42) | RPS6KA5LATS1PRMT5WDR77NTRK1 | |
| SCHEMBL29955602 | 0.68 | KMT2A (0.54) | RPS6KA5LATS1NTRK1 | |
| SCHEMBL3434268 | 0.68 | KMT2A (0.54) | RPS6KA5LATS1NTRK1 | |
| SCHEMBL1272426 | 0.67 | HTR2A (0.64) | HTR2AHTR2CHTR2B | |
| SCHEMBL6654177 | 0.67 | HTR2A (0.64) | HTR2AHTR2CHTR2B | |
| SCHEMBL30996123 | 0.66 | NTRK1 (0.40) | RPS6KA5NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664996-A | Indole derivative and preparation method thereof | INST MEDICINAL BIOTECHNOLOGY | 2014-03-26 | — | — | CN | disclosed |
| CN-103534257-A | Pyrrolo [2, 3 -d] pyrimidine derivatives as inhibitors of tropomyosin- related kinases | PFIZER | 2014-01-22 | — | — | CN | disclosed |