Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GCK | P35557 | 14/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27742604 | 0.88 | GCK (0.45) | SMN1; SMN2GCKRAB9AGAAKMT2A | |
| SCHEMBL1328829 | 0.81 | GCK (0.61) | SMN1; SMN2GCKRAB9AGAAKMT2A | |
| SCHEMBL27761676 | 0.72 | RAB9A (0.52) | SMN1; SMN2RAB9AGAAKMT2ANPC1 | |
| SCHEMBL27763161 | 0.70 | GCK (0.57) | SMN1; SMN2GCKRAB9AGAAKMT2A | |
| SCHEMBL1329730 | 0.70 | GCK (0.50) | SMN1; SMN2GCKRAB9AGAAKMT2A | |
| SCHEMBL1329654 | 0.70 | GCK (0.57) | SMN1; SMN2GCKRAB9AGAAKMT2A | |
| SCHEMBL1328957 | 0.70 | GCK (0.70) | GCKRAB9AGAAKMT2AADORA2A | |
| Hydrochloric Acid SCHEMBL1330168 | 0.69 | GCK (0.69) | GCKRAB9AGAAKMT2AADORA2A | |
| SCHEMBL27741171 | 0.69 | GCK (0.46) | SMN1; SMN2GCKRAB9AGAAKMT2A | |
| SCHEMBL1329776 | 0.69 | GCK (0.61) | GCKRAB9AGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437816-B | 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC | 2013-08-14 | — | — | CN | claimed |